I am a dermatologist, and I think I can be qualified to talk about acne treatment. But the first thing I want to tell you is that acne treatment must be a long-term treatment. Even after it is completely under control, if you are under stress, have an irregular diet, or have a sweet tooth, stay up late and so on, there is a possibility that new pimples may grow out.

It is important to clearly recognize that acne is one of the more obvious facial skin features of adolescence. Early intervention is very necessary, and can reduce the formation of facial skin acne marks and pits, especially those who have more inflammatory papules, cysts and nodules, it is more important to be in the regular hospital dermatologists under the guidance of an effective treatment to determine whether it is necessary to take oral antibiotics or vita-acid medication for a full course of treatment.

It is important to realize that you should take medication when you should and not take medication when you shouldn't. For example, oral isotretinoin capsules can act on the main pathogenesis of acne, can be very effective in reducing acne as well as inhibit the recurrence of acne. However, isotretinoin also has certain side effects, such as dry skin and liver and kidney function abnormalities, as well as elevated blood sugar and blood lipids, young women can not get pregnant during the period of taking the drug and three months after stopping the drug and so on. Therefore, you should take the drug under the guidance of a regular doctor.

Of course, it can also be treated with some of the more classic topical medications, such as benzoyl peroxide gel and adapalene gel, but the onset of effect is usually about a month, and is usually more pronounced at two or three months. Therefore, it is important to be patient when using medication and to minimize side effects, such as local irritation, erythema, peeling and pain.

Don't believe in the so-called beauty salons or some organizations that claim to cure your acne. Because the beauty salon he is not a hospital, so do not treat indiscriminately and blindly.

Of course, if you visit the dermatology department of a regular public hospital, if you feel that this doctor's treatment plan is not so perfect and is often paired with excessive herbal medicines for treatment, then it is still recommended that you change your dermatologist for treatment.

In conclusion, acne treatment is a constant healing process of fighting against it, and apart from needing the help of your doctor, you need to take proper care of your life yourself.

I have a best friend, greasy, face acne, think a lot of ways, also went to the Nanjing Skin Hospital, such as the formal specialty hospital for examination and treatment. I've taken a lot of medication, but my skin hasn't gotten much better. The first time you eat spicy will be even worse, so that she even spicy hot pot is almost quit.

Later, by chance, I heard a female owner of a clothing store talk about her own formula for curing her face, went back and insisted on it for a year, and it really got better!

It is not medicine, is therapeutic food, should be to regulate the body's internal mechanism, balance the endocrine what brings the effect, from the inside out.

I'm copying out this recipe, so if you can trust it, take it, but if you can't, laugh it off and don't blame me for cursing me. Anyway, I can confirm that my bestie does have better skin.

Silver fungus a little soaked, add lotus seeds 5, 6, red dates 3, 4, lily 7, 8 pieces, rock sugar appropriate amount (according to taste), evening with baby BB pot stewed for more than 8 hours, every morning as breakfast to take.

The key is to keep taking it, and you can see the results in as little as a month or as long as half a year. She looks younger than the rest of us at her age.

Thanks for the invitation to answer the question.

First, it is important to understand what acne is and why it occurs. It is generally recognized that acne is a chronic inflammatory skin disease, which is more common among teenagers and is known as "pimples". From the perspective of traditional Chinese medicine, acne is related to dampness-heat constitution. People with dampness-heat constitution can easily condense water and dampness into phlegm, and the stagnation of dampness-heat for a long period of time will turn into heat, which will stagnate the skin and block the hair orifices, thus giving rise to acne. Ge Hong, a famous doctor in the Jin Dynasty, pointed out in "After Elbow Preparation" that "young people are full of gas, face with blisters." This means that young people are prone to acne when they are full of qi and yang.

Being prone to acne does not mean that acne is inevitable. "Youthfulness is a characteristic of adolescents, but it is not a necessary condition for acne. Exuberant energy, if reasonably protected and used, will make the youthful face clean, full of vitality, but if the opposite will be counterproductive. I know a boy, this is tall and handsome, youthful vigor and talent, but has grown a face of small acne, so handsome in the lack of distress. Doctors diagnosed that like to stay up late, love to drink cold drinks and other bad habits, is the cause of its acne. This is because the cold water poured on him at the time of Yang Qi's growth and development will result in Qi stagnation! At the same time, the doctor warned that life stress and poor diet can also lead to acne.

From this, the author, after deliberation, to provide advice on a few. First, the correct mindset, to their own decompression and burden reduction, to maintain a comfortable mood, a good mindset or half. The second is to develop good habits, regular work and rest, as little as possible to stay up late, less cold drinks, less barbecue and snacks, eat less alien or anti-seasonal fruits, corn, vegetables and other foods. Third, from the collection of prescription for a prescription: morpholine guanidine hydrochloride tablets 20 tablets, metronidazole tablets 10 tablets, Shunfeng Kangwang cream 1, lincomycin lidocaine gel (green ointment) 1 box, tablets crushed and mixed with the cream, apply a few times a day.

The causes of the disease are many and it is prudent to seek outpatient treatment. We wish our patients and friends a speedy recovery!

Acne, also known as pimples and acne vulgaris, is caused by the exuberant secretion of androgens in the human body during puberty, which is normal. When a person enters puberty, the secretion of androgens in the human body will become more, which will make the sebaceous glands overgrown, and the walls of the follicle tubes will be keratinized, and the lumen of the tubes will be blocked so that the sebaceous glands can not be discharged, resulting in the production of sebaceous plugs, which is the so-called acne.

Improving and treating acne can be done in the following ways:

Use of sulfur soap

Use sulfur to wash your face. Sulfur soap is alkaline and skin oils are acidic, so washing your face with an alkaline soap balances the pH level.

topical cream

Acne places, you can apply some treatment of acne ointment, but under the guidance of the doctor to use medication, adhere to the use will gradually improve. If there are infections, such as redness, swelling, fever, pain, you can apply erythromycin ointment, which has anti-inflammatory properties, be aware that penicillin has allergies to the population, prohibit the use of mupirocin.

Retinoic acid, retinol, vitamin A, etc. These can improve keratinization and act as a soothing or removing agent for acne. Benzoyl peroxide treats acne by applying it to the acne area, which gradually releases oxygen and has a nice antiseptic effect.

oral medicine

For more severe acne, oral isotretinoin is the standard treatment, and is by far the most effective way to treat acne.

Permanent flowers for acne

When the flowers bloom, pick some fresh permanent flowers, wash your face with warm water before going to bed at night, rub the flowers with your hands to get the flower juice, apply it to the acne, repeatedly rubbing to no juice, the next day, get up early and wash it off, adhere to a week of acne obviously disappeared.

spiritual pleasure

A good mood is good for the treatment of acne. Don't be psychologically burdened by acne to avoid neuroendocrine disruption, which can make acne worse.

Acne is aChronic inflammatory nature of follicular sebaceous glandsA skin disease with a prevalence of 70% to 87%. There are many ways to get rid of acne, and some treatments are of uncertain efficacy, lacking evidence-based medical evidence to support them, and individual methods may even cause damage to patients. Therefore, it is essential to standardize the treatment of acne by popularizing how to effectively treat acne.

One,catering：

Limit spicy, sweet and greasy foods that may trigger or aggravate acne, especially foods that are high in sugar and calories, and eat more vegetables and fruits;

II. Daily life:

Avoid staying up late, prolonged exposure to computers, exposure to the sun, etc. Pay attention to facial skin cleansing, moisturizing and reducing sebum secretion, and keep your bowels clear;

(iii) Psychological diversion:

Acne patients, especially those with severe acne, are more prone to anxiety, depression and other psychological problems. According to Chinese medicine theory, liver depression will seriously affect the operation of qi and blood, which will lead to sores over a long period of time, so it is very important to have a calm state of mind.

IV. Facial cleansing：

You should choose water or a suitable cleansing product to remove a mixture of excess oil, flakes and bacteria from the surface of the skin, but you should not over-wash. What's more, you should not regularly hand squeeze or scratch lesions such as acne and inflammatory pimples.

V. Daily care:

In some acne patients, the skin barrier is damaged and long-term oral or topical use of anti-acne medications such as retinoids tends to exacerbate the damage to the skin barrier, leading to skin sensitization. Therefore, in addition to medication, physical therapy, chemical peeling, sometimes it is also necessary to use efficacious skin care products to maintain and repair the skin barrier function. If accompanied by skin sensitivity, should be used externally soothing, oil-control moisturizing cream, local lesions can be used with anti-acne skin care products; if the skin shows greasy, large pores and other symptoms, the main choice of oil-control moisturizing gel.

VI. Oral and external treatment with traditional Chinese medicine:

The oral treatment of acne with herbs requires a dialectical approach.wind-heat in the lungsFor those who have such symptoms, use Pei Pa Kao Lung Cleansing Drink or Diabai San with additional subtractions.dampness and heat in the spleen and stomachIf the patient is in need of treatment, use Artemisia capillaris or Scutellaria baicalensis flat stomach powder with additional subtraction.condensation of phlegm and stasis (TCM)For evidence, use Seaweed Jade Pot Soup or Peach Red Four Substances Soup.lack of balance between men and womenFor those who have evidence, they can use Easy Pill, Zhi Bai Di Huang Wan, Zuo Gui Wan, Liu Wei Di Huang Wan and so on.

External treatments in Chinese medicine such as herbal wet compresses:Amaranthus, Purslane, Phellodendron BarkThe water decoction wet compress, 2 times a day, each time 20 min, for inflammatory papules, pustular lesions, play a heat detoxification, reduce the role of inflammation.

I think back to last year's acne scene, heart palpitations! Finally how good it, go to the skin hospital to see, ask the reason for acne, the doctor said a whole lot, what the endocrine, what stress, what mood swings, a variety of reasons are there is no indication of the specific long direct cause, the treatment time of half a year, the method: eat drugs + topical ointment + red and blue light + anti-inflammatory masks, the drug is anti-inflammatory + acne, anti-inflammatory drugs, anti-inflammatory drugs, in the middle of the change of three, every one and a half months of eating to change a kind of anti-inflammatory drugs, the medicine is fixed one: isotretinoin soft capsules, at first eat nearly a month felt no effect at all, a little disappointed with the doctors The acne medicine is fixed a: isotretinoin soft capsule, at first ate nearly a month feel no effect at all, the doctor was a little disappointed, sprouted the idea of not wanting to continue to eat, and then the doctor said that anti-inflammatory drugs is to insist on eating at least a month and a half to eat to have an effect, and then really ate two months to start to see the effect, first of all, did not continue to grow, and then slowly inflammation of redness and swelling of those who began to get better, the process of After cleaning my face every night, I use the Vitamin E ointment prescribed by the doctor to wipe my face to hydrate, and then use topical ointment to wipe the acne (two ointments: adapalene to wipe small acne, benzoyl peroxide gel to wipe large acne), take the medication at the same time to go to the hospital to do a week of red and blue light + anti-inflammatory mask treatment, I am the first three months of the first three months of the week to go to a time, and then did not go to the last three months! The treatment process, the face will be very dry, to rub more Vitamin E ointment, other maintenance products I dare not use, and now the face is good, a year did not recur, I remember the last time I went to the hospital follow-up, the doctor also suggested that I do laser acne marks, quite expensive, a course of three times, more than 10,000 yuan, but also can not be reported to the social security system, at that time, I did not do. One is quite expensive two is to slow down, see if it will recur and then decide to radical not laser, fortunately, did not do, because the acne did not break the mouth, the mouth of those who are very ripe acne is very ripe when the mouth is not going to leave scars, so there is no acne pits on the face, only a few red marks, the red marks half a year time on the fade, a year of basically a lot of them are gone, playing a thin foundation on the can not be seen! At that time, really depressed ah, the treatment of the six months, life is worse than death! So long acne fairies, must keep the mood calm, comfort themselves, will be good, sleep time to ensure sufficient, avoiding food is a must, sunscreen work to do a good job, do not have to take a long time on the good!

Modern medicine believes that acne is related to endocrinology. Too much androgen in the body leads to exuberant secretion of sebaceous glands, and as soon as there is too much oil, the bacteria (Propionibacterium acnes) settling in the glands will multiply rapidly, causing inflammatory reactions in the hair follicles and sebaceous glands.
The advantages of western medicine in treating acne are direct, targeted and fast-acting, such as internal antimicrobials, retinoic acid preparations, anti-androgen therapy, etc., and topical antimicrobial ointments, retinoic acid ointments, chemical peels, etc;

Side effects are taking antibacterial drugs may cause dysbiosis, easy to drug resistance; Vitamin A acid preparations may have liver and kidney damage, the impact on the bones, fetal teratogenicity, etc., internal hormone drugs may cause chloasma, so not too serious acne try to external treatment and topical application of Western medicine-based.

The advantage of Chinese medicine lies in holistic conditioning, what is holistic conditioning? What is holistic management? It is to consider the whole body, taking into account menstruation, gastrointestinal function, sweating function, and so on. For example, I sometimes prescribe "Warm Menstruation Soup", which is a medicine to regulate menstruation, and when menstruation is regulated, acne will get better; sometimes I prescribe "Pueraria Mirifica Soup", which is a medicine to promote sweating, and the inflammation will subside; sometimes I prescribe "Semixia This is a medicine for treating the spleen and stomach, and after taking it, the bloating of the stomach and the irregularity of the bowels will be relieved, and the acne will also improve.

Therefore, Chinese medicine treatment is more concerned about the whole body, but purely internal Chinese medicine will be slower and more moderate compared to Western medicine, to be combined with external Chinese medicine treatment such as fire acupuncture, acupuncture, Chinese herbal masks can speed up the healing.

Regardless of the method, acne must be treated by type, severity, and location.

1, acne type acne: divided into whitehead acne and blackhead acne.

Whiteheads, also known as closed pimples, are caused by lipid plugs blocking the openings of hair follicles; blackheads, also known as open pimples, are formed when the surface of the lipid plugs is oxidized by air;whiteheadsblackheads and pimples

The main treatment for acne is oil control, exfoliation, and pore shrinkage. The main methods include red and blue light irradiation, fruit acid exfoliation, and topical application of adapalene gel.

2, pimples pustular acne: is the inflammation of the pimples, some of them are red grains, some of them have pustules at the top, is relatively shallow inflammation;

Western medical treatment is mainly antibacterial, oil control, adjust the follicle keratinization and so on. Such as oral minocycline or doxycycline, viamin ester, topical antibacterial creams such as clindamycin gel, Bansai and so on;

External treatments in TCM include acupuncture, fire acupuncture, herbal fumigation, and external application of herbal masks.

3、Nodular cystic acne: inflammation of the deep layers of hair follicles and surrounding tissues, this inflammation is deep, extensive, and serious called polymerized acne, which may leave scars if not treated in time.

Western medical treatments include oral antimicrobials, glucocorticoids, and topical antimicrobial ointments;

Traditional Chinese Medicine (TCM) uses fire needling, bloodletting, and external application of Jinhuang paste.

4, acne pits, acne marks

Commonly used treatments include microneedling, fractional lasers, and radiofrequency.

Acne is also a chronic inflammatory skin disease, acne must go to the regular hospital for medical treatment, their own indiscriminate application of medication, squeezing pimples, excessive exfoliation, may induce or aggravate acne, or left acne scars.

(This is Dr. Chen Mengxue from the Dermatology Department of Fuzhou Hospital of Traditional Chinese Medicine, if you have any questions, you can leave a comment under the article to let me know)

Feel free to follow the headline to get more of the skin science you want!

The good news is that patients with advanced non-small cell lung cancer (NSCLC) who have an epidermal growth factor receptor (EGFR)-sensitive mutation have the opportunity to be treated with targeted drugs that have better efficacy and fewer side effects than traditional cytotoxic drugs! These targeted drugs are known as Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and include the first-generation drugs Gefitinib and Erlotinib, the second-generation drugs Afatinib and Daclatinib, and the third-generation drugs Gefitinib and Erlotinib, as well as the third-generation drugs Afatinib and Daclatinib. EGFR-TKIs have proven efficacy and play an important role in the treatment of advanced NSCLC, including the first-generation drugs gefitinib and erlotinib, the second-generation drugs afatinib and daclatinib, and the third-generation drug ositinib, among others.

However, with the widespread use of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) targeted drugs and the prolongation of the time patients take the drugs, the side effects of these drugs have become more and more obvious, including skin rash, oral mucositis, onychomycosis, loss of appetite, diarrhea, malaise, liver function impairment, and interstitial lung disease, and so on. Serious side effects can reduce the patient's quality of life and adherence to medication, and even affect the effectiveness of antitumor therapy.

What to do, don't worry! Pharmacists are here to help you with a series of tips to crack the epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) side effects plague one by one.Let's talk about "how to deal with acne-like rashes" with the appearance community today.

Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) class of drugs in the mutant epidermal growth factor receptor (EGFR) effect at the same time, but also affects the wild-type epidermal growth factor receptor (EGFR) signaling, and the human body has a large number of epithelial tissues of the epidermal growth factor receptor (EGFR), the patient taking epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) will affect the epidermal growth factor receptor (EGFR) signaling in the epithelial tissue, resulting in the blockage of skin metabolism, which leads to inflammation and the formation of a rash.

These rashes tend to be pustular or papular, with blotchy, itchy, dry, flaky and ulcerated skin; they are most common on areas with a high sebaceous gland distribution, i.e., the scalp, face, and upper trunk; they usually begin to appear in the first 2 weeks of treatment, peaking in the third week, and stabilizing around 4 weeks of treatment.

Our oncologists, based on the NCI CTCAE version 4.0 gradingThe rash was categorized as mild, moderate and severe.

• It is mildly limited to the head, face and upper trunk, with almost no subjective symptoms, no impact on daily life and no secondary infections.
  
  

• Moderate rashes are more extensive, have mild subjective symptoms, have a mild impact on daily life, and may have localized infections with no signs of secondary infections.
  
  

• Severe rashes are widespread, have severe subjective symptoms, have a greater impact on daily life, and have the potential for localized and secondary infections.

划重点！!

Can Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI)-induced rashes be prevented? Of course it can, take it:

First and foremost, it's all about sun protection.When you go out, you can wear a hat, umbrella, pay attention to avoid sun exposure, or minimize the time of sun exposure. Targeted drugs are often photosensitized, especially small molecule inhibitors (pharmacist reminder: epidermal growth factor receptor - tyrosine kinase inhibitors (EGFR-TKI) are small molecule tyrosine kinase inhibitors oh)! For exposed skin, use a broad-spectrum sunscreen with SPF ≥15, UVA/UVB protection, and paraben-free.

Next, remember to moisturize.Starting from the treatment with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), it is important to keep the body clean every day, as well as moisturize the skin in the dry areas, you can use alcohol-free moisturizing lotion on the whole body 2 to 3 times a day, don't touch the alkaline and irritating toiletries, and avoid the hot water bath (of course, it is not a requirement to take a cool bath to avoid catching a cold and getting a flu, but to use lukewarm water so that you don't Avoid hot water bath (of course, it is not required to take a cool bath to avoid cold and flu, but use lukewarm water, so as not to feel overheated), and apply a mild moisturizing lotion in time after the bath.

In addition, it is very important to make sure that you take your medication the right way!For epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) drugs, you can usually choose to take them orally at least 1 hour before a meal or 2 hours after a meal; at the same time, also avoid drinking fruit juices containing grapefruit, grapefruit ingredients, so as not to affect the absorption of these foods in the body of the EGFR-TKI drugs and cause the blood drug concentration to rise and may lead to a rash. EGFR-TKI drugs may affect the absorption of the drugs in the body, resulting in an increase in the concentration of the drugs in the blood, which may lead to rash.

Finally, for the sake of face value, it is inevitable to avoid eating!Remember to eat a light diet with less fat and sweets, avoid spicy and stimulating foods, do not drink alcohol, eat more fruits and vegetables, and keep your bowels clear.

Knock on wood!!!

What treatments are available for epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-induced rashes once they occur?

When a rash occurs, the first step is to determine the severity and then proceed with a cascading process ofThe general principles are: mild rash, general observation or local medication is sufficient; moderate to severe, in addition to local medication, oral medication is also required.

Mild rash:

Topical 1% or 2.5% hydrocortisone cream can be used without any form of intervention and can be applied to the affected area every night before bedtime (but is not recommended for the face);

For dry skin with itching, apply thin phenol glycerin lotion or benadryl ointment to the itchy area twice daily. Do not change the dose of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) because of a mild rash. reassess the extent of the rash after 2 weeks, and treat the rash as moderate if it worsens or does not improve significantly.

Moderate rash:

Topical medium - strong potency hormones such as 0.1% hydrocortisone butyrate or 0.1% mometasone furoate are applied once a day at bedtime, which can be changed to every other day after the symptoms have resolved, and not more than 14 consecutive days (pulsatile administration is recommended for patients with a long duration of the rash: discontinue for 7 days after 14 consecutive days of use, and then continue to be used);

10% clindamycin gel, 1% clindamycin ointment, or erythromycin ointment, applied externally twice daily for no more than 14 consecutive days; oral antihistamines, such as paracetamol 4mg tid or chlortetracycline 10mg qd, may be given as appropriate;

If the skin is dry with itching, benadryl ointment or compound benzoic acid ointment can be applied topically once or twice a day; if necessary, minocycline 100mg qd or doxycycline 100mg bid can be taken orally. the rash will be reassessed after 2 weeks, and if the situation worsens or there is no significant improvement, then it will be treated as a severe rash.

Severe rash:

Monitor the rash and reduce the dosage of EGFR-TKI; topical hormones should be 1% hydrocortisone butyrate ointment or 0.1% mometasone furoate ointment (same as for "moderate rash"); shock dose of methylprednisolone 0.4mg/kg/d or prednisone 0.5mg/kg/d for up to 10 days can be given as necessary; the rash can be monitored and the dosage can be reduced as needed. If necessary, a shock dose of methylprednisolone 0.4mg/kg/d or prednisone 0.5mg/kg/d can be given orally for up to 10 days;

If serious conditions such as pus, cracking or blistering are present in combination with infection, then the appropriate antimicrobial drug is selected for treatment, such as oral cefuroxime 250 mg bid, or a 14-day regimen of memantine (i.e., minocycline) (first dose of 0.2 g in adults, followed by an additional 0.1 g orally every 12 or 24 hours, or as directed by a physician);

Those who do not respond well to antibiotics may be systematically treated with low-dose isotretinoin 20 to 30 mg/d in two divided doses. If the rash does not resolve sufficiently or worsens after 2 to 4 weeks, suspend or permanently discontinue treatment with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) analogs.

In addition to the above methods for preventing or treating rashes caused by epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI), pharmacists have the following great tips to try!

Tip #1:Wash your face with dried honeysuckle boiled in water, or boil concentrated honeysuckle water to cool, soak it in a blank mask and apply it wet to the head, face, neck and other rash areas.

Tip #2:After cleansing your face with aloe vera cleanser, apply a topical lotion made with rose oil, or use aloe vera juice to gently apply to the rash.

Myojo 3:If accompanied by itching, you can use a mild shampoo with anti-dandruff and anti-itching properties as a body wash, and you can also use a glycerite lotion to apply to the itchy skin.

Finally, one more piece of advice is that you should not scratch the rash area with your hands, so as not to cause skin breakage and infection!

In fact, epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-induced rashes, although of high incidence, are not of high severity, with the incidence of severe rashes being only about 7%, and, theThe editor has one more piece of good news from the press:

Rash, a signal that the targeted therapy is working well Oh! This news has been confirmed by the results of many authoritative studies.

Therefore, we do not have to be too anxious about the rash caused by the epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) class of drug therapy, so many wonderful tricks, there is always a suitable choice for the patient!

Reviewer: Guangdong Pharmaceutical Society Zhongshan University Cancer Prevention and Control Center Zhuojia Chen

Answers provided above by Liu Tao, Guangdong Pharmaceutical Society, Sun Yat-sen University Cancer Center!

痤疮It is a chronic inflammatory disease that occurs in the sebaceous glands of the hair follicles, with a high incidence, favoring the face, and often accompanied by scar formation in severe cases, which seriously affects aesthetics.

Causes of AcneIt is more frequent and the pathogenesis is complex. The occurrence of acne is closely related to many factors such as excessive sebum secretion, elevated androgen levels, abnormal keratinization of the sebaceous gland ducts of the hair follicles, bacterial infections and inflammatory reactions.

1. The pathophysiologic basis of acne is the rapid development of sebaceous glands and the excessive secretion of sebum.The development of sebaceous glands is directly governed by androgens, and elevated levels of androgens promote the development of sebaceous glands and the production of large amounts of sebum.

:: 2. Abnormal keratinization of follicular sebaceous gland ductsis another important factor, and this expansion is secondary to the blockage of follicular sebaceous gland ducts by abnormally keratinized keratinocytes, obstruction of sebaceous gland drainage, and eventual formation of keratin plugs.

3. Bacterial infections:Impaired secretion and expulsion of large amounts of sebum predisposes to secondary bacterial infections, of which Propionibacterium acnes infections are the most important. The esterases produced by Propionibacterium acnes break down the triacylglycerols in sebum to produce free fatty acids, which are a major contributor to inflammatory damage in acne.

Therefore, all current medications for acne are theorized to work by intervening in several of these areas. The following is a description of the medications that can be used for acne by the pharmacists at Escape:

1. Antimicrobial drugs:Common antimicrobial drugs used to treat acne include clindamycin, erythromycin, roxithromycin, memantine, polytetracycline, and metronidazole.

2. Anti-androgenic drugs:Spironolactone, compound cyproterone acetate and so on. Spironolactone, also known as Andriolactone, is an aldosterone analog, and its mechanism of action is: ① Competitively inhibit the binding of dihydrotestosterone to the receptor of the skin target organ, thus affecting its action and inhibiting the growth of sebaceous glands and sebum secretion. ② Inhibit 5-alpha reductase and reduce the conversion of testosterone to dihydrotestosterone. It is widely used in the treatment of acne because of its cheap price and low toxic side effects.

3. Isotretinoin-based drugs:Oral isotretinoin is the standard treatment for severe acne and is currently the most effective treatment for acne. Isotretinoin acts on all pathophysiologic aspects of acne pathogenesis, and although the therapeutic effect is significant, it is minimally used as the treatment of choice for mild acne given its adverse effects.

4. Vitamin drugs:Vitamin B6, Vitamin C, Vitamin Bco, Vitamin E, and Niacinamide. Vitamin B6 is a coenzyme of many amino acids and is involved in the metabolism of amino acids, fats, and carbohydrates, and is an adjunct to the treatment of acne.

5. Proprietary medicines:Antelope Angle Drops, Wan Ying Capsules, Yi Qing Capsules, Tanshinone Capsules, Bear Gall Capsules and so on. These proprietary Chinese medicines treat acne by clearing heat and removing toxins, cooling blood and other effects. Among them, tanshinone has estrogen-like effect, inhibits Acinetobacter and anti-inflammatory effect, which is effective in treating inflammatory acne, and at the same time can inhibit sebum secretion.

6. Corticosteroids:Dexamethasone, prednisone, methylprednisone, etc. Glucocorticoids have the ability to suppress androgen secretion caused by hyperadrenocorticism, anti-inflammatory and immunosuppressive effects. Oral glucocorticoids are mainly used in fulminant acne or coalescing acne, as these types of acne are often associated with excessive immune response and inflammation. Oral administration is only used in patients with more severe inflammation and in small, short-term doses.

7. Topical medications:Chlorazol cream, acne lotion, ciprofloxacin gel, selenium disulfide lotion, adapalene (retinoid) gel, benzoyl peroxide gel (which can be one of the topical antimicrobials of choice for inflammatory acne), mupirocin ointment, fusidic acid cream, and erythromycin ointment.

8. Anti-allergy drugs:Ebastine, loratadine, desloratadine, imipramine, ketotifen, and others.

9. Immunomodulatory drugs:Thymosin, compound glycyrrhizin tablets, etc.

Acne pimples seem to favor me, as a senior patient, to share my experience of acne and its cure!

Oily skin is a hotbed of acne, and unfortunately, I inherited my father's oily skin and acne! Since junior high school, my back always felt itchy in winter, and I didn't know what was going on at first, but I slowly developed a small pimple on my forehead, which felt very similar to the one on my back, and then I realized that the pimple on my back was also acne! Since then this acne on my body home, a home is more than ten years! In fact, middle school, high school and college during the acne, but belong to the normal range of acne, for the appearance of no special care I can accept, are in the forehead, in addition to the obvious pimples do not have pores clogged small pimples all over the face of the phenomenon!

The point is, a year after graduating from college, I do not know whether it is a change in the living environment or just work pressure or what reason, the spring of the second year after graduation, forehead pimples seem to have experienced the spring rain bamboo shoots, almost every pore is a small pimple, and slowly there is inflammation into acne, previously clean cheeks also began to grow pimples, especially after the wedding photos that year, the face on the burst, the temples have grown! ...... I had no confidence at that time, and I felt that everyone I met at the door was looking at and talking about my face, so I really wanted to hide it for myself! The first time the face of the acne seriously, because of the relationship between colleagues with a well-known direct marketing health products, there is a cleanser can be shot out of the pores of the small particles, coupled with the needle clear, to do the anti-inflammatory mask, hydrating mask, with its green packaging that set of skincare, adhere to the two or three months, to be honest, I really don't think there is an improvement! There is a balancing cream said to be used for a long time can be water and oil balance, but really do not feel, give up! I went to the hospital, opened a bunch of anti-inflammatory drugs detoxification drugs, ate the effect is not obvious! Beauty salon needle clearing mask, and with the perfect almost, left too serious acne marks, are purple and black acne marks! The endocrine changes during pregnancy and breastfeeding, acne less! After weaning slowly acne again up ...... heart blocking ah! The middle of the Chinese medicine, eat some kind of protein as the main ingredient of the health care products, and finally really no trick on the no matter!

However, this time my face full of acne nemesis came! Back home that year, I met my aunt, said my cousin in a cure acne effect how good, recommended that I go, I smiled calmly, and met my cousin said more sincere, have to pull me to go, can not wipe the face to go, really did not think of the effect!

After my cousin's appointment, I was the first customer to wake up early, full of acne, many are inflamed with whiteheads! To that clear acne beauty tired enough, a whole hour and a half, to me are squeezed out, especially the chin and neck of the inflamed pimples, to my pain straight cry ah! I think at that time fortunately endured over! The normal process is to apply her family special effects acne mask, because at that time to catch the train, the beauty of her family anti-inflammatory Chinese medicine, and the special effects of the mask powder for me to take with me, and urged me to do this mask at night! Then there are several kinds of medicine, pore collection, acne, anti-inflammatory, acne marks, and used in the face of the nodule, anyway, a whole lot of medicine, a strong flavor of Chinese medicine ......

Squeeze after the third or fourth day, the face began to peel, in fact, was clear of the acne in repair, so hard to full reduce squeeze acne, the skin is also to be injured, so a large area to clear the acne in the middle of the best interval of more than five days! After a week, the damage to the skin is almost repaired, you will feel the face is flat and soft and tender a lot, this change is very let me joy! The next month acne marks also fade amount almost, people around me are very surprised at the improvement of my skin, heart secretly happy ah! As acne is more serious, it is not possible to clear all at once, about half a year later I went back to the trip, this time waiting for the skin to repair the good later, basically is normal skin!

Here are a few points of my experience: 1. acne or to go to the good reputation of the specialized acne beauty institutions, especially in severe acne skin, ordinary beauty salons to do daily care no problem, acne may not be so professional; 2. health care products can only have a certain role in assisting the effect of acne can not talk about the effect of the 3. skincare products to the main hydration and moisturizing, less make-up, do a good job cleaning, at least ensure that you have to wash your face before going to bed, make-up! Makeup must be removed! Do a good job of sunscreen, damage to the skin, especially acne marks are very easy to sunburn and leave spots; 4. Each person according to their own situation to find out the causes of aggravation of acne for self-targeted adjustment! I personally eat spicy not much effect on acne, but fried food junk food eat too much will aggravate acne, sleep late will also aggravate acne!

Good night, folks, I'm going to get my beauty sleep!