Drugs for AIDS, can they be developed?
1996.He Daiyi's team has succeeded with hybrid therapy, which involves the simultaneous use of 3-4 anti-AIDS drugs, each of which works separately at different points in the HIV reproductive cycle, and can effectively inhibit viral replication and keep the disease under control.
This therapy is similar to the mixing and blending of cocktails, and He Da Yi then named it Cocktail Therapy.
When the news was announced, the whole medical world was sensationalized. After being overshadowed by AIDS for more than 10 years, mankind finally saw the brightest dawn.
In the clinic, it was verified that after a few weeks of treatment, 7 out of 10 patients showed significant improvement, persistent low-grade fever and skin ulcers disappeared, and their energy level increased, and in some cases no trace of HIV could be detected in their blood. 3 years later, the patients who had received the cocktail of therapies were still living their lives as normal people.
In countries where cocktail therapies are widely used, the mortality rate for people with AIDS has dropped to 20 per cent; with timely treatment, patients "live as long as they normally would".
Elvin Johnson, the American basketball superstar, contracted HIV in 1991. With the help of cocktail therapy, 27 years have passed so far, and at the age of 59, he still appears in all kinds of activities like a normal person and becomes a successful businessman.
At an awards ceremony honoring outstanding Asians, Johnson personally presented an award to Daichi Ho for saving his life.
This therapy is recognized as the most effective current treatment for AIDS, but it is not perfect.The core disadvantages are: patients need to take the medication for years without interruption, and the toxic side effects of the medication can affect patients in different ways.
In developed countries, AIDS patients can take the right drugs from a range of more than 30 medications with fewer side effects. However, in countries with limited medical care, patients suffer more serious side effects from taking generic or alternative medicines, "some patients have very realistic nightmares in the first few weeks of taking them; some lose fatty tissue in their face and arms".
Cocktail therapy is also not the end of AIDS, "It can only largely control, but not completely cure, AIDS; it still won't help those who are too ill to fully recover." Long-term drug users also still have to deal with the problem of drug resistance.
In March 2014, Daiyi He and his team successfully developed a novel antibody, GSK 744LA. After experiments in apes and monkeys, which metabolize the drug faster than humans, a single shot of the novel antibody can keep them free of HIV infection for three months. If human trials are successful, it could serve as an effective transition until a vaccine emerges.
Although the true effectiveness will depend on the results of the Phase III human trials, this achievement has already made waves in the medical community once again.
Robert Grant, an HIV treatment expert, sees Daiichi Ho as a "game changer" in HIV prevention, he laments:"This is the most exciting news in HIV prevention research that I know of."
We hope that Dr. Ho Tai-yi's trial will yield good results and cure more AIDS patients soon.
I specialize in AIDS prevention and I'll answer that.
AIDS has been a source of fear since its discovery, and with decades of research, the treatment of HIV has faced enormous challenges. At present, the spread of AIDS has been effectively controlled, various types of testing and control results continue to emerge, the cocktail therapy proposed by Chinese-American Professor He Da Yi has been effectively applied, but only to a certain extent to control the disease, so far there is no cure and its drugs. Therefore, can we really develop drugs to treat AIDS?
AIDS, or Human Acquired Immunodeficiency Syndrome, is a systemic immune system disease caused by the Human Immunodeficiency Virus (HIV), a virus that mainly infects human T-lymphocytes, causing the gradual death of CD4+ T-lymphocytes, resulting in the loss of human immunity. HIV is an RNA virus that can reverse transcription, the RNA strand enters the cell nucleus and implants its own genes into the DNA of normal cells, which is difficult to separate, and creates more infected cells with each division of human cells, making it difficult to cure AIDS.
However, the University of Hong Kong announced in April 2018, the University's research team has developed a new type of antibody drug that can protect cells from being infected by HIV and remove the virus of AIDS, the drug has been successfully tested on mice. It is understood that the drug can bind to the CD4 protein on the surface of the host immune cells, which can carry out a "precision strike" against the HIV virus, but also protect healthy cells, thereby controlling the spread of HIV. However, the drug has not been applied to the clinic, the specific therapeutic effect is yet to be proved, but its results have been preliminary research and development of AIDS drugs hope.
Although it is difficult to see a cure for AIDS in a relatively short period of time, the research at the University of Hong Kong is well on its way and is getting closer and closer to the World Health Organization's goal of ending AIDS by 2030, and a cure for AIDS is on the horizon.
I am in the CDC professional to do AIDS prevention and treatment work, there are about AIDS related issues can be concerned about private letter advice Oh, thank you.
It was used clinically in the 1990sHighlyActive AntiretroviralTherapy (HAART)Treatment of AIDS, that is, we are all very familiar with the cocktail therapy, his inventor is also a Chinese-American scientist, called He Dayi, with this invention, He Dayi won the 1996 Time Magazine Man of the Year.
The invention of cocktail therapy is a milestone event in the treatment of AIDS. Cocktail therapy can effectively inhibit the reproduction of HIV, reduce the mortality rate of patients and improve the quality of life. HoweverCocktail therapy does not 'cure' AIDS, it only controls the condition to a certain extent.But even so the birth of cocktail therapy has transformed AIDS from an incurable death sentence to an incurable but manageable chronic disease.
Today, there are more than 30 medications available for the clinical treatment of AIDS.
They can be categorized into six groups depending on the antiviral mechanism :
①Protease Inhibitor (PI)Inhibits HIV protease activity, targets the final stages of HIV replication, and hinders the formation of the HIV protein coat, relatively expensive
②IntegraseStrand TransferInhibitor (INSTI)The process requires the involvement of the integrase enzyme, which can inhibit the activity of the integrase enzyme and thus inhibit the replication of HIV after it enters human T cells.
③FusionInhibitor (FI)The first step for HIV to enter a cell requires the fusion of the virus with the cell membrane of a human T-cell, and these drugs can block the fusion process and thus prevent HIV from entering the T-cell.
④CCR5 receptor inhibitorHIV has to bind specifically to the CCR5 receptor on the surface of human T-cells before it can enter the cell, and these drugs are CCR5 receptor inhibitors that block the specific binding.
⑤核苷类逆转录酶抑制剂 (Nucleoside Reverse Transcriptase Inhibitor, NRTI)The most prominent AIDS drug, and the most diverse, is very active with HIV reverse transcriptase and inhibits viral reproduction by competitively inhibiting the blockage of reverse transcriptase.
⑥非核苷类逆转录酶抑制剂 (non—nucleosidereversetranscriptaseinhibitor, NNRTI)The first is to target HIV reverse transcriptase, which inhibits HIV reproduction by inhibiting its activity.
HIV now has a smaller chance of being cured if intervention is made early in the infection, but the vast majority of cases still involve controlling the progression of the disease, reducing mortality and improving the quality of life of the patient.The biggest challenge in curing AIDS is that the virus mutates and hides in areas of the brain, such as the nerves, where drugs cannot reach, and then waits for the opportunity to cause repeat infections.
Anti-AIDS drugs are now 225.4331. and smz, but there doesn't seem to be any potent ones for AIDS, I'm sure there's hope, it's rumored that Butcher's Onyx has some effect on AIDS!
Some folk Chinese medicine is said to be able to treat AIDS, but the country is still not explicitly recognized, but also in the experimental process, Chinese medicine must have a way to solve this problem, some people in the silent research, the need for international and domestic forces to work together to overcome this medical problem! Must be able to!
Drugs to treat HIV have been researched for years, there just isn't a complete cure for HIV (human immunodeficiency virus) at this time.
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at the present timeDomestic treatment of AIDSfree (of charge)Antiviral treatment medicines have been various zidovudine, stavudine, desipramine, lamivudine, nevirapine, indinavir, efavirenz.These are commonly known as "first-line drugs,"The State distributes drugs free of charge to AIDS patients.Commonly known as "second-line drugs" in China are Crestor and Tenofovir. "Second-line drugs are not free. Patients have to pay for them.Although the worldAt present, there is no complete cure for AIDS drugs, but early detection and early treatment of AIDS patients on the drug compliance is good, after taking drugs in the blood can reach the detection of HIV (HIV). Through scientific treatment, the life expectancy of AIDS patients is basically not much different from that of normal people, and it is basically close to the life expectancy of normal people. RealityMany viruses are difficult to kill.如Herpes simplex virus (HSV),Hepatitis B virus (HBV) cannot be completely cured, only clinically functional cures that can be controlled for the rest of your life.Science and technology are advancing rapidly, and a vaccine for HIV may soon be developed in the near future. Drugs to cure HIV. It will not be too far away.
Drugs to treat AIDS, per se.
Domestic AIDSfree (of charge)Antiviral therapy medicines are: zidovudine, stavudine, desipramine, lamivudine, nevirapine, indinavir, efavirenz.
These are first-line drugs.
The point is that it's free, and it's also is that the state is handing out free drugs to people with AIDS.
The main second-line drugs in the country are kleenex and tenofovir. Not free.
There are more advanced medications and treatment options available in the United States. Check out the information to learn more if you are interested.
At present, there is no drug that can cure AIDS, however, it is not a big problem to control the disease, basically, AIDS patients can survive for many years through scientific medication, which can be close to the normal life expectancy.
In fact, many viruses are very difficult to kill.
For example, there is no complete cure for Hepatitis B. There is only a clinical cure, which means that it can be controlled to the point of lifelong freedom from the disease.
The good thing is that there is a Hepatitis B vaccine, and it has also become common for newborns to be fully vaccinated, which greatly reduces the rate of infection.
It is believed that in the near future, with the advancement of science and technology, a vaccine for AIDS will also be successfully developed.
That would be a blessing for all mankind.
Hello! Thank you for your invitation! This friend raised this question, I will briefly answer. AIDS is an "immortal cancer", which can only be controlled by medication, but these medications cannot cure the disease!
Tendon therapy, along with drinking the right amount of ginger powder and toning the five internal organs can be improved. Because ginger can detoxify all poisons! Tendon dialing therapy is the body's poisonous gas and fire 🔥 gas can be discharged out of the body, as well as the blood on the disease, not nonsense at all. I just know, just for reference 😔😱😱😱
Treatment of HIV medication has long been there, commonly known as "cocktail", patients need to take every day on time, before and after not worse than 30 minutes or so to take, it is best to do so on time, so that the drug is tolerated by the patient once on the drug, need to take medication for life, can not take the liberty to cut off the medication, HIV is mainly attacking the body's immune cells, once the body's immune system is damaged, along with what diseases may occur. The human immune system is damaged, with what disease may appear, as for the cure of HIV special drugs, so far the world has not been developed, the world's only recognized as a cure for the "Berlin patient", this case also let people see a ray of light, but with the continuous progress of medical science and technology, gene therapy, kicking the law and so on in-depth exploration and research, I believe that there will always be a cure. However, with the continuous progress of medical technology, gene therapy, kick removal method and other in-depth exploration and research, I believe that one day will break this world problem!
AIDS has been around for decades since its discovery. It has always been a high prevalence of the disease in the world, and although it is under control, there is still no cure for all of it, and there is no effective medicine. Can only control the recurrence of the disease. This immune deficiency syndrome medical records and cancer disease is as difficult to cure. Drug research and development for decades also have no special drugs.
I hope that the study will be conducted earlier.
We hope that domestic and foreign high-tech medical professionals will cooperate sincerely and increase the investment of medical funds, and hope that new drugs and vaccines will be developed in 10 to 20 years, so as to benefit the patients' early recovery. ......
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