Hi, I'm a doctor who works at the CDC on HIV and other infectious diseases, so let me give you an answer.

Since AIDS was first discovered in the United States in 1981, more than 40 million people around the world have been infected with HIV, and more than 20 million people have died of AIDS or AIDS-related illnesses. Nearly 40 years have passed, and although there have been many breakthroughs in the treatment of AIDS, there has been no scientific research progress towards a complete cure for AIDS.

This leads us to wonder why no drug has been developed to cure AIDS.

I would like to explore the following three aspects:

I. Mutagenicity of HIV

In fact, not only the AIDS virus, there are only a few viruses that mankind can deal with at present, for example, even the most basic cold and flu viruses, we can not deal with. HIV is a single-stranded negative-stranded RNA virus, which has a strong ability to mutate very quickly. Therefore, it is very difficult to deal with HIV because drugs work on the initial virus but not on the mutated virus.

II. HIV integrates into the body's DNA

As shown in the figure, the HIV virus that infects the human body will eventually be integrated into the human body's DNA, so neither drugs nor the body's immune system can kill it, and at this stage of the treatment is to inhibit the replication of the HIV virus. In a recent study, scientists have successfully utilized gene editing technology to knock out the RNA of HIV integrated into the DNA of mice, which has the potential to become a future direction for curing AIDS.

Third, the world's large consortia hold the relevant technology

There are so many drugs for the treatment of AIDS, all developed by some of the top drug companies in the world, such as Tenofovir developed by Gilead. These consortia will lose a lot of income if AIDS is completely cured. For example, according to the years of protection of patented drugs, the patent protection period of a drug is only so many years. Tenofovir Generation I (TDF) developed by Gilead is a very good drug for treating AIDS and Hepatitis B, but it has osteotoxicity and nephrotoxicity, and it is about to reach the patent expiration date, and as a result, it has developed Tenofovir Generation II (TAF). While this is only a guess, there is reason to believe that these technologies are held by the world's big money players.

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The key to this question is not knowing what AIDS is. As well as not understanding human immunity.

AIDS is different from other diseases in that it destroys the immune system. People rely on their immune system to cure the disease, drugs are an aid. To get rid of it, it all depends on the immune system. And when the immune system is broken, it's easy for anything to come in.

That's why AIDS can't be cured yet. Theoretically, all one has to do is come up with a drug that can overcome AIDS without hurting the immune system. The reality is that to cure AIDS you have to hurt immunity.

Hiv is a cell that constantly attacks the body's resistance, cd4.

On the whole, medicine is improving.

In the beginning, there was no medication at all, and the foreigners were basically waiting to die, and then in the later stages, they started to develop zidovudine, nevirapine, and other things that the rich could take.

Then in '96, the cocktail therapy (through a combination of three drugs) researched by Chinese scientist Da-Yi Luo achieved the same level of life expectancy as normal people (except for drug damage)

In fact, it's only been 30-40 years since the disease was discovered, so can you say it hasn't been cured at all? Not really. The most famous cure was a bone marrow transplant in Berlin, but there are certain conditions!

So, the big picture is still good, it's just a matter of how long we wait.

AIDS is nothing. How many patients can there be? Immune deficiencies can last a lifetime as long as they are taken care of, but what about the suffering of cancer patients?

High blood pressure has been around for 200 years and there is no cure; diabetes has been around for 300 years and there is no cure; in fact, almost all chronic diseases are terminal and require long-term medication. In fact, almost all chronic diseases are terminal and require long-term medication. AIDS is just a chronic, infectious disease that kills people.

It's as if smoking has been known to be harmful for decades, so why doesn't the state ban it. I summarize three points: first, increase the economy consumption tax, second, increase the consumption and tax of medical institutions, and third, effectively reduce the time after retirement to collect social security. This is the kind of person the country needs the most.

Personally, I think it's better not to develop it for the following reasons:

1. Drug-using population:

You're already on drugs and you still don't care about getting AIDS? AIDS may not be so scary in a world of lustful hallucinations.

2. People who sell blood:

It's not too easy to get blood from regular sources, and the black market blood sellers don't care if you can't get it. The black market blood buyers don't care about you, they will reuse it if they have to.

3. Promiscuous people:

I guess this is the biggest beneficiary of the development of the AIDS cure. I'm afraid there will be even more promiscuity by then!

Surely there are others who would say mother-to-child transmission? First of all, the baby is certainly innocent, but his/her mom is missing! Why does he/she get it? No more than the same three scenarios above.

All of the above are personal views, and do not agree or do not like the welcome to discuss, but hope not to scold. Thank you.

Not only AIDS ah, specifically should all antiviral drugs do not directly kill the virus, viruses and bacteria are not the same, viruses survive by replication, bacteria is reproduction, in short, it is the microorganisms between living and non-living things, you say he is a living thing to put he is not by reproduction to survive, you say he is a non-living thing (such as stone), he can continue through the replication, and can also be mutated!

First of all, this can not count on the domestic, national conditions, the people want you to develop new drugs sold at a price of cabbage, that is basically to the closure of the pharmaceutical company, the United States Pfizer before invested 7 billion to engage in research and development, failure, resulting in the company's financial report is particularly difficult to see, and the recent research and development of treatment of frozen people's medicine, 12 w a, you want to sell this price in the country, Iron will certainly every day at the door of the trouble, so you can only count on foreign countries. The second hiv is a rna virus, mutability is strong, so even more bad R & D.

Medicine many times is not progressive, it is often a case of there is or there isn't or there isn't. As soon as the 1st generation of drugs is researched closely followed by the 234th generation comes out very quickly. Is generally the first generation of drugs or the balance of the active ingredients and side effects on the human body need to invest a long time and a great deal of experience to complete. And even if they are researched, they still have to go through all kinds of experiments and observation periods before they can be released. This is true not only for AIDS, but for all kinds of drugs.