Thank you for inviting me. Early symptoms may be different for each patient, generally speaking, patients will experience generalized fatigue and weakness, stiffness in the joints of both hands, and inflexibility in clenching and expanding the fists, especially after waking up in the morning, so it is also known as morning stiffness. Some patients also experience swelling and pain in the joints of both hands at first. In some patients, the symptoms are not obvious, and the physical examination reveals positive rheumatoid factor, elevated blood sedimentation and c-reactive protein, therefore, the early manifestations of the patients are all different. If you have any of the above manifestations, you should go to the rheumatology and immunology department of the hospital as soon as possible, in order to seek early diagnosis and early treatment. Hope it helps!