Has the new coronavirus mutated? Brazilian patient's viral gene is different from Wuhan sample in 3 places, how to deal with it?
Neocollins do mutate, some become stronger, some become weaker, but in general they are still similar. So as long as the virus is still called "neococcal pneumonia", then the treatment is basically the same and there is not much difference, so there is nothing to worry about.
Take Brazil as an example, Brazil is the 2nd announced that the country confirmed the diagnosis of two cases of new coronary pneumonia patients, after genetic sequencing found that the two new coronary pneumonia patients in the body of the virus is different, a case with Germany's virus is similar to a case of virus similar to the United Kingdom, and both cases of the virus is different from China's virus. Medical researchers at the University of São Paulo in Brazil say the mutations in the viruses are imprints of the spread of the outbreak in the areas concerned, and can be used by researchers to track the path of the virus. But whether the virus mutates stronger or weaker, I think it can be treated with a combination of Chinese and Western medicine. It is only that in the process of treatment, the ingredients of the prescription are different, the dosage is different, and then with the cooperation of Western medicine, both internal and external, the symptoms and root cause of the virus will be cured, no matter how much the virus has mutated.
There is a saying how to say, it is strong by it strong, the bright moon shines on the river, it is weak by it weak, the wind brushes the hillock. Although the virus has mutated, medical treatment is also evolving and improving, so no matter how the new crown virus changes, it will eventually be deciphered by the researchers, and by then, no matter what the virus has become, human beings have the appropriate treatment means to cope with it, so the new crown pneumonia will eventually be completely cured inevitably, definitely, absolutely, it is only a matter of time, just sooner or later.
It is ideal to believe that the virus is now spreading more and more widely, which means that the path of transmission of the virus will also become more and more numerous, so that the virus will continue to mutate for some time to come, and therefore, mankind must always track the mutation and change of the virus, and the whole world must fully cooperate in tackling the problem, so that only in this way can we early develop effective medicines against the virus as well as the various kinds of mutated viruses, and ultimately, can we completely cure the patients suffering from the virus. Therefore, based on the fact that the virus is mutating, all countries in the world must cooperate and share the results, and only by coming up with a global program can the virus be eliminated globally. I believe that as long as a special drug for viruses is developed, a special drug for mutated viruses can be developed on the basis of it. Therefore, the key to curing the global viruses still lies in China, and it still relies on China.
News reports, Brazil's first confirmed case of neocoronavirus and Wuhan announced that there are three different genes compared to the virus, that is, the virus in the process of transmission has been mutated. Through the largest molecular evolutionary analysis of the entire genome of 103 new coronaviruses to date, the Chinese research team found that the virus strain has recently undergone 149 mutations, resulting in the evolution of two subtypes, the L subtype and the S subtype, with the L subtype accounting for 70 percent of the mutations and the S subtype accounting for 30 percent of the mutations. The S subtype is a relatively older version, while the L subtype is more aggressive and infectious. These two studies have amply demonstrated that some mutation has occurred in the new coronavirus.
Why do new coronaviruses mutate? What can be done about it?
Virtually all coronaviruses are more prone to mutation because coronaviruses are single-stranded RNA viruses, which are more prone to mutation than double-stranded DNA viruses. Due to the lack of RNA polymerase, viruses are prone to errors when replicating RNA, and there is no way to predict what will go wrong during replication that will lead to mutation of the virus. More than a hundred mutation points occur compared to more than 30,000 bases, which is actually within the normal range of mutations. However, if the mutation changes the characteristics of the virus itself, such as its infectiousness, virulence, etc., this should attract our attention. Whether our current therapeutic drugs are still effective against the mutated virus, whether the current preventive and control measures are still effective against the virus, whether the vaccine researched is effective against the virus, and so on, these series of questions need more research before we can reach a conclusion.
Therefore, from the present point of view, the diagnosis and treatment of infected persons should be accompanied by early control of transmission. Contact tracing for neocoronaviruses is being conducted to prevent infection and thus curb human transmission of neocoronaviruses as much as possible.
Welcome to like, forward, leave a message, I am physician Yang Hao, focusing on common diseases, multiple diseases diagnosis and treatment, chronic disease management, health science. If you want to know more about medical knowledge, welcome to pay attention to this headline!
The viral mutations in question are to be viewed with caution:
1. Sequencing methods in Brazilian laboratories are not exactly the same as in Wuhan, and errors between laboratories are inevitable, sometimes large enough to misclassify a mutation.
2. Some laboratories use three-generation sequencing with an error of 10% to 20%.
3. New coronaviruses are RNA viruses, and errors in RNA sequencing are more likely.
4,To address the effect of mutation on protein function, it is important to look at its effect on the spatial structure of proteins, and to look at the effect on the ability of viruses to infect human cells, and to look at the results of animal experiments.
5,Whether or not the mutation leads to a worse outbreak depends on which protein the mutation is on, some proteins are associated with infectivity and some with reproductive capacity. If the mutation leads to greater infectivity and faster reproduction, then it is possible that the outbreak will be exacerbated. But it is possible that the opposite is true, that the mutation makes it less infectious and slower to reproduce, which is good for controlling the outbreak.
Now (2020.3.4 statistics) in the global circulation of the new crown virus IQ has been in the constant toss up to 724. This will obviously lead to the original will not be hit by the character but will be accidentally hit.
Staying at home and not going anywhere will minimize the chances of infection. It's the frontline medical staff, frontline workers and frontline volunteers who suffer, mankind owes you so much!
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